Tenure-Track-Prof. Dr. Andreas J. Gruber


Andreas J. Gruber is a Tenure-Track Professor of Applied Bioinformatics at the University of Konstanz. He holds Bachelor and Master degrees in both fields Biotechnology and Software Development. For his doctoral research on the transcriptional and post-transcriptional regulation of gene expression he joined the Biozentrum of the University of Basel in Switzerland, from which he obtained a PhD in the subject area of Bioinformatics. In 2018, Andreas joined the Oxford Big Data Institute of the Nuffield Department of Medicine, University of Oxford, where he conducted research in the field of cancer genomics and transcriptomics as well as on the development of data science tools that enable to study human health and disease. In 2020, he joined the Division of Cancer Sciences of the University of Manchester, where he worked on the characterization of molecular features observed within multiple large cancer patient cohorts. In 2021, Andreas joined the University of Konstanz as a Tenure-Track Professor of Applied Bioinformatics. His research group works on the development of data science approaches and tools that enable to study human health and disease, with a focus on the analysis of molecular mechanisms underlying cancer development and progression as well as the immune response to virus infections.

Research-related publications

  • Gruber AJ/Gypas F/Riba A/Schmidt R/Zavolan M. Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms, in: 2018, Nature Methods, Oct;15(10):832-836. (https://doi.org/10.1038/s41592-018-0114-z) (Co-corresp. Author)
  • Gruber AJ/Zavolan M. Alternative cleavage and polyadenylation in health and disease, in: 2019, Nature Reviews Genetics. Oct;20(10):599-614. (https://doi.org/10.1038/s41576-019-0145-z) (Co-corresp. Author)
  • Gruber AJ/Schmidt R/Ghosh S/Martin G/Gruber AR/van Nimwegen E/Zavolan M. Discovery of physiological and cancer-related regulators of 3' UTR processing with KAPAC, in: 2018, Genome Biology, Mar 28;19(1):44. (https://doi.org/10.1186/s13059-018-1415-3)
  • Gruber AJ/Grandy WA/Balwierz PJ/Dimitrova YA/Pachkov M/Ciaudo C/Nimwegen Ev/Zavolan M. Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways, in: 2014, Nucleic Acids Research, Aug;42(14):9313-26. (https://doi.org/10.1093/nar/gku544)
  • Gruber AJ/Schmidt R/Gruber AR/Martin G/Ghosh S/Belmadani M/Keller W/Zavolan M. A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation, in: 2016, Genome Research, Aug;26(8):1145-59. (https://doi.org/10.1101/gr.202432.115)