Jour Fixe: "The Science and Fiction of Ageing" (Special Jour Fixe on topic of the year "Ageing")
Dienstag, 13. November 2018
15.15 – 16.45 Uhr
Volodymyr Shvadchak (Researcher at the Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic)
Parkinson's and Alzheimer's diseases are two most-common neurodegenerative disorders. Both of them affect predominantly aged people, both of them are connected to protein misfolding, and both of them, unfortunately, are yet incurable. In my work I focus on one of possible approaches to stop or delay progression of those diseases, namely, on suppressing misfolding of proteins into amyloid fibrils. We are designing compounds able to stop growth of amyloid fibrils composed of α‑synuclein, the main component of pathological inclusions during Parkinson's disease. If the development of such drugs is successful, in the future they will allow blocking Parkinson's disease progression at early stages.