Autumn School - Programme

Sunday, 24 September 2017

TimeProgramme                                                                                      Location/Room
19:00             Welcome Reception                                                                                                          Restaurant Stromeyer - Die Bleiche,
Bleicherstrasse 8                

Monday, 25 September 2017

TimeProgramme                                                                                      Location/Room
Bioconjugation Chemistry
9:00

Bioconjugation of Biopolymers, Bioorthogonal Chemistry | Andreas Marx

This talk will highlight and introduce the most important approaches for biorthogonal chemistry covering a large variety of chemistries.

Y311
10:20Coffee breakY311
10:40

Affinity Probes & Labeling Strategies – From Concepts to Applications | Thomas Böttcher

This talk will focus on the application of bioconjugation chemistry for proteomic labeling strategies and protein profiling with chemical probes. Active site-directed probes targeting enzyme activities in complex proteomes have become an important tools for chemical biology. Hereby also various techniques for the cellular target profiling of small molecules will be discussed.

Y311
12.00-13:30LunchMensa, K7
Combinatorial and High Throughput Technologies
13:30

Small Molecule Screening | Thomas U. Mayer

The talk will provide an overview of the spectrum of small molecule screening ranging from in vitro protein-based screens to high-content screens in cells. We will highlight the pros and cons of the different screening strategies and discuss optimal screening conditions using examples of screens performed in the in-house screening facility. A particular focus will be on the challenge of target identification and specificity analyses of identified compounds. If desired, we will have a tour of the screening center.

Y311
15:00Coffee breakY311
15:30

Combinatorial Protein Design: Screening and Selection | Andreas Marx

This talk will highlight and introduce the most important approaches for evolving improved or new protein functions. Thereby, several screening and selection strategies will be covered.

Y311                               

Tuesday, 26 September 2017

TimeProgramme                                                                                  Location/Room
Computational Life Science
9:00

X-Ray Structure Analysis | Kay Diederichs

Knowledge of the structures of macromolecules is a prerequisite for understanding their functions and interactions. The talk will present important aspects of the theory and application of X-ray crystallography, the method that contributes about 90% of the macromolecular structures known today.

Y311     
9:50Coffee breakY311  
10:05

Biomolecular simulation | Christine Peter

The talk will provide an introduction into classical molecular dynamics simulations. Such simulations provide a molecular view on biological systems and processes, they can be used to analyse the interplay of different types of relevant interactions, and they serve as a basis for a microscopic mechanistic interpretation of processes such as folding, binding, or aggregation.

Y311  
10:55Coffee breakY311  
11:10

Advanced (Life Science) Data Analysis | Michael Berthold

The talk will provide an overview of classic and modern techniques for the analysis of various types of data: molecular databases, images, sequences, and mass spectrometry data. We will show how to process and integrate this type of data using the open source platform KNIME using extensions such as RDKit (chem informatics), SeqAn (NGS), FIJI (images), and OpenMS (mass spec).

Y311  
12:00-13:00LunchMensa, K7
Optical Spectoscopy in Life Science
13:00

IR-Spectroscopy | Karin Hauser

The course will focus on IR-spectroscopy to study structure, function and dynamics of biomolecules ranging from small peptides to membrane proteins. Practical information (sample forms, sample preparation), various methods (FTIR, ATR, IR-laser spectroscopy) and aspects of data acquisition and analysis will be presented. Examples to study protein reaction mechanisms with time-resolved IR-spectroscopy will be given.

Y311
14:20Coffee breakY311
14:40

Fluorescence Techniques | Andreas Zumbusch

This part will cover fluorescence techniques. After a short introduction to fluorescence spectroscopy, examples for application of fluorescence detection especially in the microscopy of biological samples will be given.

Y311                                

27 – 29 September 2017

International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology