Ausgewählte Publikationen

Sailer C, Offensperger F, Julier A, Kammer K, Walker-Gray R, Gold MG, Scheffner M*, and Stengel F* (2018). Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex. Nat. Commun. accepted.

Kropp HM, Dürr SL, Peter C, Diederichs K, and Marx A (2018). Snapshots of a modified nucleotide “moving” through the confines of a DNA polymerase. Proc. Natl. Acad. Sci. USA accepted.

Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Funk JO, Langrish CL, and Groettrup M (2018). Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. in press.

Huang W, Haferkamp I, Lepetit B, Molchanova M, Hou S, Jeblick W, Río Bártulos C, Kroth PG (2018). Reduced vacuolar β-1,3-glucan synthesis affects carbohydrate metabolism as well as plastid homeostasis and structure in Phaeodactylum tricornutum. Proc. Natl. Acad. Sci. USA 115, 4791.

Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schütz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M*, and Wiesner S* (2018). The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat. Commun. 9, 3321.

Aschenbrenner J, Werner S, Marchand V, Adam M, Motorin Y, Helm M, and Marx A (2018). Engineering of a DNA polymerase for direct m6A Sequencing. Angew. Chem. Int. Ed. 57, 417.

Pingen D, Zimmerer J, Klinkenberg N, and Mecking S (2018). Microalgae Lipids as a Feedstock for Production of Benzene. Green Chem. 20, 1874.

Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, and Groettrup M (2018). Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation. Kidney Int.  93, 670.

Rao A, Drechsler M, Schiller S, Scheffner M, Gebauer D, and Cölfen H (2018). Stabilization of Mineral Precursors by Intrinsically Disordered Proteins.  Advanced Functional Materials - ISSN 1616-301X.

Kunkel M, Schildknecht S, Boldt K, Zeyffert L, Schleheck D, Leist M, and Polarz S (2018). Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards. ACS Appl. Mater Interfaces 18, 23638.

Dhodary B, Schilg M, Wirth R, and Spiteller D (2018). Secondary Metabolites from Escovopsis weberi and Their Role in Attacking the Garden Fungus of Leaf-Cutting Ants. Chemistry 24, 4445.

Wang C, Sinn M, Stifel J, Heiler AC, Sommershof A, and Hartig JS (2017). Synthesis of All Possible Canonical (3'-5'-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects. J. Am. Chem. Soc. 15, 16154.

Zhao X, Lutz J, Höllmüller E, Scheffner M, Marx A, and Stengel F (2017). Identification of Proteins Interacting with Ubiquitin Chains. Angew. Chem. Int. Ed. 56, 15764.

Xiao C, Li M, Wang B, Liu MF, Shao C, Pan H, Lu Y, Xu BB, Li S, Zhan D, Jiang Y, Tang R, Liu XY, and Cölfen H (2017). Total morphosynthesis of biomimetic prismatic-type CaCO3 thin films. Nat. Commun. 8, 1398.

Witt T, Haussler M, Kulpa S, and Mecking S (2017). Chain Multiplication of Fatty Acids to Precise Telechelic Polyethylene. Angew. Chem. Int. Ed. 56, 7589.

Spitzbarth M, Scherer A, Schachtschneider A, Imming P, Polarz S, and Drescher M (2017). Time-, spectral- and spatially resolved EPR spectroscopy enables simultaneous monitoring of diffusion of different guest molecules in nano-pores. Journal of magnetic resonance (San Diego, Calif. : 1997) 283, 45.

Ruiz-Agudo E, Burgos-Cara A, Ruiz-Agudo C, Ibanez-Velasco A, Cölfen H, and Rodriguez-Navarro C (2017). A non-classical view on calcium oxalate precipitation and the role of citrate. Nat. Commun. 8, 768.

Robotta M, Cattani J, Martins JC, Subramaniam V, and Drescher M (2017). Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. J. Am. Chem. Soc. 139, 4254.

Picker A, Nicoleau L, Burghard Z, Bill J, Zlotnikov I, Labbez C, Nonat A, and Cölfen H (2017). Mesocrystalline calcium silicate hydrate: A bioinspired route toward elastic concrete materials. Sci. Adv. 3, e1701216.

Mundt S, Basler M, Sawitzki B, and Groettrup M (2017). No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Molecular immunology 88, 32.

Hess SK, Schunck NS, Goldbach V, Ewe D, Kroth PG, and Mecking S (2017). Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach. J. Am. Chem. Soc. 139, 13487.

Gao HL, Chen SM, Mao LB, Song ZQ, Yao HB, Cölfen H, Luo XS, Zhang F, Pan Z, Meng YF, Ni Y, and Yu SH (2017). Mass production of bulk artificial nacre with excellent mechanical properties. Nat. Commun. 8, 287.

Cattani J, Subramaniam V, and Drescher M (2017). Room-temperature in-cell EPR spectroscopy: alpha-Synuclein disease variants remain intrinsically disordered in the cell. Phys. Chem. Chem. Phys. 19, 18147.

Jiang Y, Kellermeier M, Gebauer D, Lu Z, Rosenberg R, Moise A, Przybylski M and Cölfen H (2017). Growth of organic crystals via attachment and transformation of nanoscopic precursors. Nat. Communications. 8, 15933.

Szamosvári D, and Böttcher T (2017). An unsaturated quinolone N-oxide of Pseudomonas aeruginosa modulates growth and virulence of Staphylococcus aureus. Angew. Chem. Int. Ed. 56, 7271.

Koerner J, Brunner T, and Groettrup M (2017). Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice. Oncotarget. doi: 10.18632/oncotarget.15141.

Betz K, Kimoto M, Diederichs K, Hirao I, and Marx A (2017). Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Angew. Chem. Int. Ed. 56, 12000.

Wallrodt S, Buntz A, Wang Y, Zumbusch A, and Marx A (2016). Bioorthogonally Functionalized NAD(+) Analogues for In-Cell Visualization of Poly(ADP-Ribose) Formation. Angew. Chem. Int. Ed. 55, 7660.

Hanebuth MA, Kityk R, Fries SJ, Jain A, Kriel A, Albanese V, Frickey T, Peter C, Mayer MP, Frydman J, and Deuerling E (2016). Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction. Nat. Communications 7, 13695.

Felletti M, Stifel J, Wurmthaler LA, Geiger S, and Hartig JS (2016). Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nat. Communications 7, 12834.

Sun ST, Mao LB, Lei ZY, Yu SH, and Cölfen H (2016). Hydrogels from Amorphous Calcium Carbonate and Polyacrylic Acid: Bio-Inspired Materials for "Mineral Plastics". Angew. Chem. Int. Ed. 55, 11765.

Buntz A, Wallrodt S, Gwosch E, Schmalz M, Beneke S, Ferrando-May E, Marx A, and Zumbusch A (2016). Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation. Angew. Chem. Int. Ed. 55, 11256.

Finke A, Bußkamp H, Manea M, and Marx A (2016). Designer Extracellular Matrix based on DNA-Peptide Networks generated by PCR. Angew. Chem. Int. Ed. 55, 10136.

Gehring J, Trepka B, Klinkenberg N, Bronner H, Schleheck D, and Polarz S (2016). Sunlight-Triggered Nanoparticle Synergy: Teamwork of Reactive Oxygen Species and Nitric Oxide Released from Mesoporous Organosilica with Advanced Antibacterial Activity. J. Am. Chem. Soc. 138, 3076.

Doll F, Buntz A, Späte AK, Schart VF, Timper A, Schrimpf W, Hauck CR, Zumbusch A, and Wittmann V (2016). Visualization of Protein-Specific Glycosylation inside Living Cells. Angew. Chem. Int. Ed. 55, 2262.

Kalinowska K, Nagel MK, Goodman K, Cuyas L, Anzenberger F, Alkofer A, Paz-Ares J, Braun P, Rubio V, Otegui MS, and Isono E (2015). Arabidopsis ALIX is required for the endosomal localization of the deubiquitinating enzyme AMSH3 Proc. Natl. Acad. Sci. USA 112, E5543.

Schachtschneider A, Wessig M, Spitzbarth M, Donner A, Fischer C, Drescher M, and Polarz S (2015). Directional Materials-Nanoporous Organosilica Monoliths with Multiple Gradients Prepared Using Click Chemistry. Angew. Chem. Int. Ed. 54, 10465.

Mortensen F, Schneider D, Barbic T, Sladewska-Marquardt A, Kühnle S, Marx A, and Scheffner M (2015). Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. Proc. Natl. Acad. Sci. USA 112, 9872.

Gamerdinger M, Hanebuth MA, Frickey T, and Deuerling E (2015). The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum. Science 348, 201.

Deutzmann JS, Stief P, Brandes J, and Schink B (2014). Anaerobic methane oxidation coupled to denitrification is the dominant methane sink in a deep lake. Proc. Natl. Acad. Sci. USA 111, 18273.

Qi M, Gross A, Jeschke G, Godt A, and Drescher M (2014). Gd(III)-PyMTA label is suitable for in-cell EPR. J. Am. Chem. Soc. 136, 15366.

Hafner J, Mayr MI, Möckel MM, and Mayer TU (2014). Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nat. Communications 5, 4397.

Roesle P, Stempfle F, Hess SK, Zimmerer J, Río Bártulos C, Lepetit B, Eckert A, Kroth PG, and Mecking S (2014). Synthetic Polyester from Algae Oil. Angew. Chem. Int. Ed. 53, 6800.

Kühnle S, Mothes B, Matentzoglu K, and Scheffner M (2013). The role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. Proc. Natl. Acad. Sci. USA 110, 8888.

Brandes U, Robins G, McCranie A, and Wasserman S (2013). What is Network Science? Network Science 1, 1.

Schwarzer DD, Gritsch PJ, Gaich T (2012). Mimicking Dimethylallyltryptophan Synthase: Experimental Evidence for a Biosynthetic Cope Rearrangement Process. Angew. Chem. Int. Ed. 51, 11514.

Tischer T, Hörmanseder E, and Mayer TU (2012). The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions. Science 338, 520.

Betz K, Malyshev DA, Lavergne T, Welte W, Diederichs K, Dwyer TJ, Ordoukhanian P, Romesberg FE, and Marx A (2012). KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat. Chem. Biol. 8, 612.

Karplus PA, Diederichs K (2012). Linking crystallographic model and data quality. Science 336, 1030.

Huber EM, Basler M, Schwab R, Heinemeyer W, Kirk CJ, Groettrup M*, and Groll M* (2012). Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell 148, 727.   *shared last authorship and correspondence  

Landsmann S, Luka M, and Polarz S (2012). Bolaform surfactants with polyoxometalate head groups and their assembly into ultra-small monolayer membrane vesicles.  Nat. Communications 3, 1299.

Muenzner P, Bachmann V, Zimmermann W, Hentschel J, and Hauck CR (2010). Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation. Science 329, 1197.

Noti M, Corazza N, Mueller C, Berger B, and Brunner T (2010). TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. J. Exp. Med. 207, 1057.