Valentin Wittmann - Publications

96. Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity
P. Kranaster, C. Karreman, J. E. G. A. Dold, A. Krebs, M. Funke, A.-K. Holzer, S. Klima, J. Nyffeler, S. Helfrich, V. Wittmann, M. Leist, Arch. Toxicol. 2019, in press (DOI: 10.1007/s00204-019-02642-z).
DOI: 10.1007/s00204-019-02642-z    Supporting Information - PDF (Size: 17.492k)

95. A Tripeptide Approach to the Solid-Phase Synthesis of Peptide Thioacids and N-Glycopeptides
M. J. Schöwe, O. Keiper, C. Unverzagt, V. Wittmann, Chem. Eur. J. 2019, 25, 15759-15764.
DOI: 10.1002/chem.201904688    Supporting Information - PDF (Size: 3.280k)

94. Human MRP2 Exports MC-LR but not the Glutathione Conjugate
G. Kaur, R. Fahrner, V. Wittmann, B. Stieger, D. R. Dietrich, Chem.-Biol. Interact. 2019, 311, 108761.
DOI: 10.1016/j.cbi.2019.108761

93. Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC-ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards
S. Altaner, J. Puddick, V. Fessard, D. Feurstein, I. Zemskov, V. Wittmann, D. R. Dietrich, Toxins 2019, 11, 388.
DOI: 10.3390/toxins11070388    Supporting Information - PDF (Size: 607k)

92. Machine Learning Prediction of Cyanobacterial Toxin (Microcystin) Toxicodynamics in Humans
S. Altaner, S. Jaeger, R. Fotler, I. Zemskov, V. Wittmann, F. Schreiber, D. R. Dietrich, ALTEX 2019, 36, DOI: 10.14573/altex.1904031.
DOI: 10.14573/altex.1904031    Supporting Information - PDF (Size: 1.082k)

91. Protein Spin Labeling with a Photocaged Nitroxide Using Diels-Alder Chemistry
A. Kugele, B. Silkenath, J. Langer, V. Wittmann, M. Drescher, ChemBioChem 2019, 20, 2479-2484.
DOI: 10.1002/cbic.201900318    Supporting Information - PDF (Size: 2.104k)

90. Cyclopropene Derivatives of Aminosugars for Metabolic Glycoengineering
J. Hassenrück, V. Wittmann, Beilstein J. Org. Chem. 2019, 15, 584-601.
DOI: 10.3762/bjoc.15.54    Supporting Information - PDF (Size: 2.515k)

89. Multivalent Carbohydrate-Functionalized Polymer Nanocrystals
Q. Tong, M. S. Schmidt, V. Wittmann, S. Mecking, Biomacromolecules 2019, 20, 294-304.
DOI: 10.1021/acs.biomac.8b01460    Supporting Information - PDF (Size: 2.449k)

88. Triple Orthogonal Labeling of Glycans Applying Photoclick Chemistry
V. F. Schart, J. Hassenrück, A.-K. Späte, J. E. G. A. Dold, R. Fahrner, V. Wittmann, ChemBioChem 2019, 20, 166-171.
DOI: 10.1002/cbic.201800740    Supporting Information - PDF (Size: 2.319k)

87. Conformationally Unambiguous Spin Label for Exploring the Binding Site Topology of Multivalent Systems
S. Weickert, T. Seitz, W. K. Myers, C. R. Timmel, M. Drescher, V. Wittmann, J. Phys. Chem. Lett. 2018, 9, 6131-6135.
DOI: 10.1021/acs.jpclett.8b02243    Supporting Information - PDF (Size: 2.380k)

86. Sweet surfactants: packing parameter-invariant amphiphiles as emulsifiers and capping agents for morphology control of inorganic particles
M. Voggel, R. M. Meinusch, V. Siewert, M. Kunkel, V. Wittmann, S. Polarz, Soft Matter 2018, 14, 7214-7227.
DOI: 10.1039/c8sm01091a    Supporting Information 1 - PDF (Size: 6.402k)    Supporting Information 2 - PDF (Size: 1.060k)

85. Identification of D-Amino Acid Oxidase and Propiverine Interaction Partners and their Potential Role in the Propiverine-Mediated Nephropathy
M. Y. Maier, L. Luks, O. Baudendistel, V. Wittmann, D. R. Dietrich, Chem.-Biol. Interact. 2018, 281, 69-80.
DOI: 10.1016/j.cbi.2017.12.023    Supporting Information - PDF (Size: 431k)

84. Intracellular Imaging of Protein-Specific Glycosylation
F. Doll, J. Hassenrück, V. Wittmann, A. Zumbusch, Methods Enzymol. 2018, 598, 283-319.
DOI: 10.1016/bs.mie.2017.06.015

83. Fluoro-carba-sugars are Glycomimetic Activators of the glmS Ribozyme
D. Matzner, A. Schüller, T. Seitz, V. Wittmann, G. Mayer, Chem. Eur. J. 2017, 23, 12604-12612.
DOI: 10.1002/chem.201702371    Supporting Information - PDF (Size: 5.229k)

82. Dienophile-Modified Mannosamine Derivatives for Metabolic Labeling of Sialic Acids: A Comparative Study
J. E. G. A. Dold, J. Pfotzer, A.-K. Späte, V. Wittmann, ChemBioChem 2017, 18, 1242-1250.
DOI: 10.1002/cbic.201700002    Supporting Information - PDF (Size: 2.279k)

81. Total Synthesis of Microcystin-LF and Derivatives Thereof
I. Zemskov, S. Altaner, D. R. Dietrich, V. Wittmann, J. Org. Chem. 2017, 82, 3680-3691.
DOI: 10.1021/acs.joc.7b00175    Supporting Information - PDF (Size: 3.426k)

80. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition
A. Schüller, D. Matzner, C. E. Lünse, V. Wittmann, C. Schumacher, S. Unsleber, H. Brötz-Oesterhelt, C. Mayer, G. Bierbaum, G. Mayer, ChemBioChem 2017, 18, 435-440.
DOI: 10.1002/cbic.201600491    Supporting Information - PDF (Size: 395k)

79. clickECM: Development of a Cell-Derived Extracellular Matrix with Azide Functionalities
S. M. Ruff,+ S. Keller,+ D. E. Wieland, V. Wittmann, G. E. M. Tovar, M. Bach, P. J. Kluger, Acta Biomater. 2017, 52, 159-170.
DOI: 10.1016/j.actbio.2016.12.022    Supporting Information - PDF (Size: 886k)

78. Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1
M. Fontanillo, I. Zemskov, M. Häfner, U. Uhrig, F. Salvi, B. Simon, V. Wittmann, M. Köhn, Angew. Chem. 2016, 128, 14191-14195; Angew. Chem., Int. Ed. 2016, 55, 13985-13989.
DOI: 10.1002/ange.201606449 (German)    DOI: 10.1002/anie.201606449 (English)    Supporting Information - PDF (Size: 7.021k)

77. Real-Time NMR Studies of Oxyamine Ligations of Reducing Carbohydrates under Equilibrium Conditions
O. R. Baudendistel,+ D. E. Wieland,+ M. S. Schmidt, V. Wittmann, Chem. Eur. J. 2016, 22, 17359-17365.
DOI: 10.1002/chem.201603369    Supporting Information - PDF (Size: 2.744k)

76. Regioselective Cleavage of Thioether Linkages in Microcystin-Conjugates
I. Zemskov, H. M. Kropp, V. Wittmann, Chem. Eur. J. 2016, 22, 10990-10997.
DOI: 10.1002/chem.201601660    Supporting Information - PDF (Size: 1.225k)

75. Synthetic Glycosphingolipids for Live-Cell Labeling
M. Dauner,+ E. Batroff,+ V. Bachmann, C. R. Hauck, V. Wittmann, Bioconjugate Chem. 2016, 27, 1624-1637.
DOI: 10.1021/acs.bioconjchem.6b00177    Supporting Information - PDF (Size: 2.216k)

74. Exploring the Potential of Norbornene-Modified Mannosamine Derivatives for Metabolic Glycoengineering
A.-K. Späte, J. E. G. A. Dold, E. Batroff, V. F. Schart, D. E. Wieland, O. R. Baudendistel, V. Wittmann, ChemBioChem 2016, 17, 1374-1383.
DOI: 10.1002/cbic.201600197    Supporting Information - PDF (Size: 1.127k)

73. Mechanistic Insight into Nanomolar Binding of Multivalent Neoglycopeptides to Wheat Germ Agglutinin
P. Rohse, V. Wittmann, Chem. Eur. J. 2016, 22, 9724-9733.
DOI: 10.1002/chem.201600657    Supporting Information - PDF (Size: 1.211k)

72. Distinct CCR7 Glycosylation Pattern Shapes Receptor Signaling and Endocytosis to Modulate Chemotactic Responses
M. A. Hauser, I. Kindinger, J. M. Laufer, A.-K. Späte, D. Bucher, S. L. Vanes, W. A. Krueger, V. Wittmann, D. F. Legler, J. Leukocyte Biol. 2016, 99, 993-1007.
DOI: 10.1189/jlb.2VMA0915-432RR

71. The STEAP1262-270 Peptide Encapsulated into PLGA Microspheres Elicits Strong Cytotoxic T Cell Immunity in HLA-A*0201 Transgenic Mice - A New Approach to Immunotherapy Against Prostate Carcinoma
V. L. Herrmann, D. E. Wieland, D. F. Legler, V. Wittmann, M. Groettrup, Prostate 2016, 76, 456-468.
DOI: 10.1002/pros.23136

70. -- Hot Paper -- Visualization of Protein-Specific Glycosylation inside Living Cells
F. Doll, A. Buntz, A.-K. Späte, V. F. Schart, A. Timper, W. Schrimpf, C. R. Hauck, A. Zumbusch, V. Wittmann, Angew. Chem. 2016, 128, 2303-2308; Angew. Chem., Int. Ed. 2016, 55, 2262-2266.
DOI: 10.1002/ange.201503183 (German)    DOI: 10.1002/anie.201503183 (English)    Supporting Information - PDF (Size: 1.553k)

69. Orthogonally Protected Furanoid Sugar Diamino Acids for Solid-Phase Synthesis of Oligosaccharide Mimetics
F. John, V. Wittmann, J. Org. Chem. 2015, 80, 7477-7485.
DOI: 10.1021/acs.joc.5b01049    Supporting Information - PDF (Size: 1.288k)

68. Application of the Thioacid-Azide Ligation (TAL) for the Preparation of Glycosylated and Fluorescently Labeled Amino Acids
K. Rohmer, J. Mannuthodikayil, V. Wittmann, Isr. J. Chem. 2015, 55, 437-446.
DOI: 10.1002/ijch.201500001    Supporting Information - PDF (Size: 1.932k)

67. Chapter 28. Short Synthesis of (2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b -D-glucopyranosyl)benzene and 4-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b -D-glucopyranosyl)bromobenzene
T. Seitz, C. Fleck, V. Wittmann, in Carbohydrate Chemistry: Proven Synthetic Methods, Vol. 3 (Eds.: R. Roy, S. Vidal), CRC Press, Boca Raton, 2015, 219-225.
DOI: 10.1201/b18400-31

66. Chapter 27. 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-O-p- nitrophenoxycarbonyl-a-D-glucopyranose
T. Seitz, C. Maierhofer, D. Matzner, V. Wittmann, in Carbohydrate Chemistry: Proven Synthetic Methods, Vol. 3 (Eds.: R. Roy, S. Vidal), CRC Press, Boca Raton, 2015, 215-218.
DOI: 10.1201/b18400-30

65. -- Hot Paper -- Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering
A.-K. Späte,+ V. F. Schart,+ S. Schöllkopf, A. Niederwieser, V. Wittmann, Chem. Eur. J. 2014, 20, 16502-16508.
DOI: 10.1002/chem.201404716    Supporting Information - PDF (Size: 1.257k)

Cover Profile:
A.-K. Späte, V. F. Schart, S. Schöllkopf, A. Niederwieser, V. Wittmann, Chem. Eur. J. 2014, 20, 16411.
DOI: 10.1002/chem.201405618

64. Expanding the Scope of Cyclopropene Reporters for the Detection of Metabolically Engineered Glycoproteins by Diels-Alder Reactions
A.-K. Späte, V. F. Schart, J. Häfner, A. Niederwieser, T. U. Mayer, V. Wittmann, Beilstein J. Org. Chem. 2014, 10, 2235-2242.
DOI: 10.3762/bjoc.10.232    Supporting Information - PDF (Size: 1.119k)

63. Efficient Labelling of Enzymatically Synthesized Vinyl-Modified DNA by an Inverse-Electron-Demand Diels-Alder Reaction
H. Bußkamp, E. Batroff, A. Niederwieser, O. S. Abdel-Rahman, R. Winter, V. Wittmann, A. Marx, Chem. Commun. 2014, 50, 10827-10829.
DOI: 10.1039/C4CC04332D    Supporting Information - PDF (Size: 553k)

62. Neues zur Physiologie des Labyrinths
H. Scherer, J. Dernedde, W. Reutter, R. Tauber, V. Wittmann, A. Niederwieser, in Vertigo - Neue Horizonte in Diagnostik und Therapie (9. Henning Symposium) (Eds.: A. Ernst, D. Basta), Springer, Wien, 2014, pp. 3-10.

61. Trendbericht Biochemie und Molekularbiologie 2013: Kohlenhydrate - mehr als nur Energielieferanten
V. Wittmann, V. F. Schart, A.-K. Späte, Nachr. Chem. 2014, 62, 306-312.
DOI: 10.1002/nadc.201490087

60. Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter
A.-K. Späte, H. Bußkamp, A. Niederwieser, V. F. Schart, A. Marx, V. Wittmann, Bioconjugate Chem. 2014, 25, 147-154.
DOI: 10.1021/bc4004487    Supporting Information - PDF (Size: 1.867k)

59. Structural Investigation of Multivalent Carbohydrate-Protein Interactions using Synthetic Biomolecules
V. Wittmann, Curr. Opin. Chem. Biol. 2013, 17, 982-989.
DOI: 10.1016/j.cbpa.2013.10.010

58. Bridging Lectin Binding Sites by Multivalent Carbohydrates
V. Wittmann, R. J. Pieters, Chem. Soc. Rev. 2013, 42, 4492-4503.
DOI: 10.1039/c3cs60089k

57. Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry
A. Niederwieser, A.-K. Späte, L. D. Nguyen, C. Jüngst, W. Reutter, V. Wittmann, Angew. Chem. 2013, 125, 4359-4363; Angew. Chem., Int. Ed. 2013, 52, 4265-4268.
DOI: 10.1002/ange.201208991 (German)    DOI: 10.1002/anie.201208991 (English)    Supporting Information - PDF (Size: 2.295k)

56. High-Affinity Multivalent Wheat Germ Agglutinin Ligands by One-Pot Click Reaction
H. S. G. Beckmann, H. M. Möller, V. Wittmann, Beilstein J. Org. Chem. 2012, 8, 819-826.
DOI: 10.3762/bjoc.8.91     Supporting Information - PDF (Size: 776k)

55. Preparation of Carbohydrate Arrays by using Diels–Alder Reactions with Inverse-Electron-Demand
H. S. G. Beckmann, A. Niederwieser, M. Wiessler, V. Wittmann, Chem. Eur. J. 2012, 18, 6548-6554.
DOI: 10.1002/chem.201200382     Supporting Information - PDF (Size: 931k)

54. Abstand halten: Aufklärung multivalenter Bindungsmechanismen
V. Wittmann, M. Drescher, Laborpraxis 2012, 36 (Februar), 42-44.
Full Text - PDF (Size: 318k)     Online Article

53. Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus
C. E. Lünse, M. S. Schmidt, V. Wittmann*, G. Mayer*, ACS Chem. Biol. 2011, 6, 675-678.
DOI: 10.1021/cb200016d     Supporting Information - PDF (Size: 4.455k)

52. Mechanism of Multivalent Carbohydrate-Protein Interactions Studied by EPR Spectroscopy
P. Braun, B. Nägele, V. Wittmann*, M. Drescher, Angew. Chem. 2011, 123, 8579-8582; Angew. Chem. Int. Ed. 2011, 50, 8428-8431.
DOI: 10.1002/ange.201101074 (German)    DOI: 10.1002/anie.201101074 (English)    Supporting Information - PDF (Size: 1.697k)

51. Preparation of Thioacid-Containing Amino Acids and Peptides and their Application in Ligation Reactions
K. Rohmer, O. Keiper, J. Mannuthodikayil, V. Wittmann, in Peptides 2010: Tales of Peptides (Proc. 31st European Peptide Symposium) (Eds.: M. Lebl, M. Meldal, K. J. Jensen, T. Hoeg-Jensen), European Peptide Society, 2010, pp. 218-219.
Full Text - PDF (Size: 477k)

50. Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray
N. Parera Pera, H. M. Branderhorst, R. Kooij, C. Maierhofer, M. van der Kaaden, R. M. J. Liskamp, V. Wittmann, R. Ruijtenbeek, R. J. Pieters, ChemBioChem 2010, 11, 1896-1904.
DOI: 10.1002/cbic.201000340     Supporting Information - PDF (Size: 13.565k)

49. Structural Basis of Multivalent Binding to Wheat Germ Agglutinin
D. Schwefel, C. Maierhofer, J. G. Beck, S. Seeberger, K. Diederichs, H. M. Möller, W. Welte, V. Wittmann, J. Am. Chem. Soc. 2010, 132, 8704-8719.
DOI: 10.1021/ja101646k     Supporting Information - PDF (Size: 5.697k)

48. Muropeptide Rescue in Bacillus Subtilis Involves Sequential Hydrolysis by b-N-Acetylglucosaminidase and N-Acetylmuramyl-L-alanine Amidase
S. Litzinger, A. Duckworth, K. Nitzsche, C. Risinger, V. Wittmann, C. Mayer, J. Bacteriol. 2010, 192, 3132-3143.
DOI: 10.1128/jb.01256-09     Supporting Information - PDF (Size: 1.690k)

47. De novo Sequencing of Peptides on Single Resin Beads by MALDI-FTICR Tandem Mass Spectrometry
A. Semmler, R. Weber, M. Przybylski, V. Wittmann, J. Am. Soc. Mass Spectrom. 2010, 21, 215-219.
DOI: 10.1016/j.jasms.2009.10.004

46. Azides in Carbohydrate Chemistry
H. S. G. Beckmann, V. Wittmann, in Organic Azides: Syntheses and Applications (Eds.: S. Bräse, K. Banert), John Wiley & Sons, Chichester, 2010, pp. 469-490.
DOI: 10.1002/9780470682517.ch16

45. Carbamate-Linked Lactose: Design of Clusters and Evidence for Selectivity to Block Binding of Human Lectins to (Neo)Glycoproteins with Increasing Degree of Branching and to Tumor Cells
S. André, D. Specker, N. V. Bovin, M. Lensch, H. Kaltner, H.-J. Gabius, V. Wittmann, Bioconjugate Chem. 2009, 20, 1716-1728.
DOI: 10.1021/bc900152w

44. Stereoselective Synthesis of 1,1'-Linked a-L-Lyxopyranosyl b-D-Glucopyranoside, the Proposed Biosynthetic Precursor of the FG Ring System of Avilamycins
M. S. Schmidt, V. Wittmann, Carbohydr. Res. 2008, 343, 1612-1623.
DOI: 10.1016/j.carres.2008.05.004

43. Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
L. Merkel, H. S. G. Beckmann, V. Wittmann*, N. Budisa*, ChemBioChem 2008, 9, 1220-1224.
DOI: 10.1002/cbic.200800050     Supporting Information - PDF (Size: 232k)

42. Glycoproteins: Properties
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), 2nd ed., Springer-Verlag, Heidelberg, 2008, pp. 1771-1793.
DOI: 10.1007/978-3-540-30429-6_44

41. Glycoproteins: Occurrence and Significance
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), 2nd ed., Springer-Verlag, Heidelberg, 2008, pp. 1735-1770.
DOI: 10.1007/978-3-540-30429-6_43

40. Unexpected formation of complex bridged tetrazoles via intramolecular 1,3-dipolar cycloaddition of 1,2-O-cyanoalkylidene derivatives of 3-azido-3-deoxy-D-allose
M. Worch, V. Wittmann, Carbohydr. Res. 2008, 343, 2118-2129.
DOI: 10.1016/j.carres.2007.10.034

39. Probing Multivalent Carbohydrate-Lectin Interactions by an Enzyme-Linked Lectin Assay Employing Covalently Immobilized Carbohydrates
C. Maierhofer, K. Rohmer, V. Wittmann, Bioorg. Med. Chem 2007, 15, 7661-7676.
DOI: 10.1016/j.bmc.2007.08.063

38. Synthesis and Application of Glycopeptide and Glycoprotein Mimetics
D. Specker, V. Wittmann, Top. Curr. Chem. 2007, 267, 65-107.
DOI: 10.1007/128_2006_104

37. Glycopeptides and Glycoproteins: Synthesis, Structure, and Application (Topics in Current Chemistry, vol. 267)
V. Wittmann (Ed.), Springer, Berlin Heidelberg New York, 2007.
DOI: 10.1007/978-3-540-36761-1

36. One-Pot Procedure for Diazo Transfer and Azide-Alkyne Cycloaddition: Triazole Linkages from Amines
H. S. G. Beckmann, V. Wittmann, Org. Lett. 2007, 9, 1-4.
DOI: 10.1021/ol0621506    Supporting Information - PDF (Size: 246k)
Rank 4 of the most-accessed articles of Organic Letters of the year 2007!

35. The Organic Chemistry of Sugars (Eds.: D. E. Levy, P. Fügedi) (Book Review)
V. Wittmann, Angew. Chem. 2006, 118, 3477-3478; Angew. Chem. Int. Ed. 2006, 45, 3399-3400.
DOI: 10.1002/ange.200685377 (German)     DOI: 10.1002/anie.200685377 (Enlish)

34. Orthogonally Protected Sugar Diamino Acids as Building Blocks for Linear and Branched Oligosaccharide Mimetics
F. Sicherl, V. Wittmann, Angew. Chem. 2005, 117, 2133-2136; Angew. Chem. Int. Ed. 2005, 44, 2096-2099.
DOI: 10.1002/ange.200462595 (German)    DOI: 10.1002/anie.200462595 (English)    Supporting Information - PDF (Size: 173k)

33. Orthogonally Protected Sugar Diamino Acids as Building Blocks for Oligosaccharide Mimetics
F. Sicherl, V. Wittmann, in Peptide Revolution: Genomics, Proteomics & Therapeutics (Proc. 18th American Peptide Symposium) (Eds.: M. Chorev, T. K. Sawyer), American Peptide Society, San Diego, 2004, 161-162.
Full Text - PDF (Size: 237k)

32. Synthetic Approaches to Study Multivalent Carbohydrate-Lectin Interactions
V. Wittmann, in Highlights in Bioorganic Chemistry: Methods and Applications (Eds.: C. Schmuck, H. Wennemers), Wiley-VCH, Weinheim, 2004, 203-213.
DOI: 10.1002/3527603727.ch2g

31. Molecular Basis of Protein-Carbohydrate Interactions
A. Lützen, V. Wittmann, in Highlights in Bioorganic Chemistry: Methods and Applications (Eds.: C. Schmuck, H. Wennemers), Wiley-VCH, Weinheim, 2004, 119-123.

30. Spatial Screening of Cyclic Neoglycopeptides: Identification of Polyvalent Wheat-Germ Agglutinin Ligands
V. Wittmann, S. Seeberger, Angew. Chem. 2004, 116, 918-921; Angew. Chem. Int. Ed. 2004, 43, 900-903.
Full Text (German) - PDF (Size: 174k)     Full Text (English) - PDF (Size: 173k)     Supporting Information - PDF (Size: 762k)

29. NMR Spectroscopic Determination of the Solution Structure of a Branched Nucleic Acid from Residual Dipolar Couplings by Using Isotopically Labeled Nucleotides
B. N. M. van Buuren, J. Schleucher, V. Wittmann, C. Griesinger, H. Schwalbe, S. S. Wijmenga, Angew. Chem. 2004, 116, 189-194; Angew. Chem. Int. Ed. 2004, 43, 187-192.
Full Text - PDF (Size: 178k)     Full Text (Int. Ed.) - PDF (Size: 179k)     Supporting Information - PDF (Size: 159k)

28. Temporary Attachment of Carbohydrates to Cyclopeptide Templates: A New Strategy for Single-Bead Analysis of Multivalent Glycopeptides
V. Wittmann, S. Seeberger, H. Schägger, Tetrahedron Lett. 2003, 44, 9243-9246.
DOI: 10.1016/j.tetlet.2003.10.078

27. Sweet Pages (Website Review)
V. Wittmann, Angew. Chem. 2002, 114, 3195; Angew. Chem. Int. Ed. 2002, 41, 3067.
Full Text (German) - PDF (Size: 51k)     Full Text (English) - PDF (Size: 55k)    

26. RNA-Targeting mit Aminoglycosid-Analoga
V. Wittmann, Nachr. Chem. 2002, 50, 1364-1368.
DOI: 10.1002/nadc.20020501219

25. Neues von der Suzuki-Reaktion
V. Wittmann, Nachr. Chem. 2002, 50, 1122-1127.
DOI: 10.1002/nadc.20020501016

24. Totalsynthesen von Callipeltosid A
V. Wittmann, Nachr. Chem. 2002, 50, 841-845.
DOI: 10.1002/nadc.20020500716

23. Dynamische kombinatorische Bibliotheken
V. Wittmann, Nachr. Chem. 2002, 50, 724-727.
DOI: 10.1002/nadc.20020500617

22. Die Totalsynthese von vermeintlichem Diazonamid A
V. Wittmann, Nachr. Chem. 2002, 50, 477-482.
DOI: 10.1002/nadc.20020500417

21. Oligosaccharidsynthese für jedermann?
V. Wittmann, Nachr. Chem. 2002, 50, 156-160.
DOI: 10.1002/nadc.20020500212

20. Copper(II)-mediated Activation of Sugar Oxazolines: Mild and Efficient Synthesis of b-Glycosides of N-Acetylglucosamine
V. Wittmann, D. Lennartz, Eur. J. Org. Chem. 2002, 1363-1367.
DOI: 10.1002/1099-0690(200204)2002:8<1363::AID-EJOC1363>3.0.CO;2-#

19. Spatial Screening of Lectin Ligands. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates
V. Wittmann, S. Seeberger, in Peptides: The Wave of the Future (Proc. 2nd International/17th American Peptide Symposium) (Eds.: M. Lebl, R. A. Houghten), American Peptide Society, San Diego, 2001, pp. 174-176.

18. Combinatorial Solid-Phase Synthesis of Multivalent Cyclic Neoglycopeptides
V. Wittmann, S. Seeberger, Angew. Chem. 2000, 112, 4508-4512; Angew. Chem. Int. Ed. 2000, 39, 4348-4352.
DOI: 10.1002/1521-3757(20001201)112:23<4508::AID-ANGE4508>3.0.CO;2-8 (German)    DOI: 10.1002/1521-3773(20001201)39:23<4348::AID-ANIE4348>3.0.CO;2-X (English)    Supporting Information - PDF (Size: 9k)

17. Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides
V. Wittmann, in Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries (Ed.: P. H. Seeberger), John Wiley & Sons, New York, 2001, pp. 99-116.
DOI: 10.1002/0471220442.ch5

16. Glycoproteins: Properties
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology, Vol. III (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), Springer-Verlag, Heidelberg, 2001, pp. 2289-2303.

15. Glycoproteins: Occurrence and Significance
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology, Vol. III (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), Springer-Verlag, Heidelberg, 2001, pp. 2253-2287.

14. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates: A Combinatorial Approach
S. Seeberger, V. Wittmann, in Innovation & Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2000 (Ed.: R. Epton), Mayflower Worldwide, Kingswinford, 2001, pp. 355-358.

13. Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives
V. Wittmann, A. K. Datta, K. M. Koeller, C.-H. Wong, Chem. Eur. J. 2000, 6, 162-171.
DOI: 10.1002/(SICI)1521-3765(20000103)6:1<162::AID-CHEM162>3.0.CO;2-9

12. Über Strukturen und Überstrukturen
T. Lindel, N. Sewald, V. Wittmann, Nachr. Chem. Tech. Lab. 1999, 47, 16-20.
DOI: 10.1002/nadc.19990470108

11. Ligand Recognition by E- and P-Selectin: Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids
V. Wittmann, S. Takayama, K. W. Gong, G. Weitz-Schmidt, C.-H. Wong, J. Org. Chem. 1998, 63, 5137-5143.
DOI: 10.1021/jo980350s     Supporting Information - PDF (Size: 233k)

10. Modified Hammerhead Ribozymes as Potential Therapeutics
J. W. Engels, M. Scherr, A. Ganser, M. Grez, V. Wittmann, Nucleosides Nucleotides 1998, 17, 1685-1696.
DOI: 10.1080/07328319808004702

9. Structural Comparison of Oligoribonucleotides and Their 2'-Deoxy-2'-fluoro Analogs by Heteronuclear NMR Spectroscopy
B. Reif, V. Wittmann, H. Schwalbe, C. Griesinger, K. Wörner, K. Jahn-Hofmann, J. W. Engels, W. Bermel, Helv. Chim. Acta 1997, 80, 1952-1971.
DOI: 10.1002/hlca.19970800614

8. 1H-Tetrazole as Catalyst in Phosphoromorpholidate Coupling Reactions: Efficient Synthesis of GDP-Fucose, GDP-Mannose, and UDP-Galactose
V. Wittmann, C.-H. Wong, J. Org. Chem. 1997, 62, 2144-2147.
DOI: 10.1021/jo9620066

7. Mechanism of a-1,3-Fucosyltransferase V: Glycosidic Cleavage Occurs Prior to Nucleophilic Attack
B. W. Murray, V.Wittmann, M. D. Burkart, S.-C. Hung, C.-H. Wong, Biochemistry 1997, 36, 823-831.
DOI: 10.1021/bi962284z

6. S- and C-Glycopeptide Derivatives of an LH-RH Agonist
K. Michael, V. Wittmann, W. König, J. Sandow, H. Kessler, Int. J. Peptide Protein Res. 1996, 48, 59-70.
DOI: 10.1111/j.1399-3011.1996.tb01107.x

5. New Peptidomimetics and Conformational Consequences
H. Kessler, E. Graf von Roedern, E. Lohof, R. Haubner, A. Geyer, V. Wittmann, in Proceedings of the 5th Akabori Conference, German-Japanese Symposium on Peptide Chemistry, May 8-12, 1994, Dresden, FRG (Ed.: E. Wünsch), Max-Planck-Gesellschaft, 1994, pp. 110-115.

4. Preparation and Transmetallation of a Triphenylstannyl b -D-Glucopyranoside: A Highly Stereo-selective Route to b-D-C-Glycosides via Glycosyl Dianions
O. Frey, M. Hoffmann, V. Wittmann, H. Kessler, P. Uhlmann, A. Vasella, Helv. Chim. Acta 1994, 77, 2060-2069.
DOI: 10.1002/hlca.19940770730

3. Synthesis of C-Glycosyl Amino Acids and their Use in Solid Phase Peptide Synthesis
V. Wittmann, H. Kessler, in Peptides 1992 (Proc. 22nd European Peptide Symposium) (Eds.: C. H. Schneider, A. N. Eberle), ESCOM Science Publishers, Leiden, 1993, pp. 369-370.

2. Stereoselective Synthesis of C-Glycosides with a Glycosyl Dianion
V. Wittmann, H. Kessler, Angew. Chem. 1993, 105, 1138-1140; Angew. Chem. Int. Ed. Engl.1993, 32, 1091-1093.
DOI: 10.1002/ange.19931050743 (German)     DOI: 10.1002/anie.199310911 (English)

1. Synthesis of C-Glycopeptides via Free Radical Addition of Glycosyl Bromides to Dehydroalanine Derivatives
H. Kessler, V. Wittmann, M. Köck, M. Kottenhahn, Angew. Chem. 1992, 104, 874-877; Angew. Chem. Int. Ed. Engl. 1992, 31, 902-904.
DOI: 10.1002/ange.19921040716 (German)     DOI: 10.1002/anie.199209021 (English)

+ These authors contributed equally.


Last update: January 19, 2020 by