C. Wang, M. Sinn, J. Stifel, A. C. Heiler, A. Sommershof, and J. S. Hartig
Synthesis of All Possible Canonical (3´-5´-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects
Journal of the American Chemical Society, 2017, doi: 10.1021/jacs.7b06141


L. A. Wurmthaler, B. Klauser, and J. S. Hartig
Highly motif- and organism-dependent effects of naturally occurring hammerhead ribozyme sequences on gene expression
RNA Biology, 2017, accepted


E. Aghdam Mehdizadeh, M. Sinn, V. Tarhriz, A. Barzegar, J. S. Hartig, M. S. Hejazi
TPP riboswitch characterization in Alishewanella tabrizica and Alishewanella aestuarii and comparison with other TPP riboswitches
Microbiology Research, 2017, 195, 71


M. Felletti, A. Bieber, and J. S. Hartig
The 3'-untranslated region of mRNAs as a site for ribozyme cleavage-dependent processing and control in bacteria
RNA Biology, 2016, doi:10.1080/15476286.2016.1240141


M. Felletti and J. S. Hartig
Ligand-dependent Ribozymes (Review)
WIREs RNA, 2016, DOI: 10.1002/wrna.1395


M. Felletti, J. Stifel, L. A. Wurmthaler, S. Geiger, J. S. Hartig
Twister ribozymes as highly versatile expression platforms for artificial riboswitches
Nature Communications, 2016, 12834


M. J. Urban, I. T. Holder, M. Schmid, V. Fernandez Espin, J. Garcia de la Torre, J. S. Hartig, H. Cölfen
Shape Analysis of DNA-Au-Hybrid Particles by Analytical Ultracentrifugation
ACS Nano, 2016, 10, 7418


M. Voges, C. Schneider, M. Sinn, J. S. Hartig, R. Reimer, J. Hauber, K. Moelling
Abolishing HIV-1 infectivity using a polypurine tract-specific G-quadruplex-forming oligonucleotide
BMC Infectious Diseases, 2016, DOI: 10.1186/s12879-016-1713-x


M. Felletti, B. Klauser, and J. S. Hartig
Screening of Genetic Switches Based on the Twister Ribozyme Motif
Methods in Molecular Biology, 2016, 1380, 225


T. Merkle, I. T. Holder, and J. S. Hartig
The dual aptamer approach: Rational design of a high-affinity FAD aptamer
Organic and Biomolecular Chemistry, 2016, 14, 447


C. Rehm, L. A. Wurmthaler, Y. Li, T. Frickey, and J. S. Hartig
Investigation of a quadruplex-forming repeat sequence highly enriched in Xanthomonas and Nostoc sp.
PlosOne, 2015, 10, e0144275,


I. T. Holder, S. Wagner, P. Xiong, M. Sinn, T. Frickey, A. Meyer, and J. S. Hartig
Intrastrand triplex DNA repeats in bacteria: a source of genomic instability
Nucleic Acids Research, 2015, 43, 10126


T. Merkle, M. Sinn, and J. S. Hartig
Interactions between Flavins and Quadruplex Nucleic Acids
ChemBioChem, 2015, 16, 2437


F. Wojciechowski, A. Groß, I. T. Holder, L. Knörr, M. Drescher, and J. S. Hartig
Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd3+-DOTA
Chemical Communications, 2015, 51, 13850


B. Strobel, B. Klauser, J. S. Hartig, T. Lamla, and F. Gantner, F. Kreutz
Riboswitch-mediated attenuation of transgene cytotoxicity increases Adeno-associated virus vector yields in HEK-293 cells
Molecular Therapy, 2015, doi: 10.1038/mt.2015.123


B. Klauser, C. Rehm, D. Summerer, J. S. Hartig
Engineering of ribozyme-based aminoglycoside switches of gene expression by in vivo genetic selection in Saccharomyces cerevisiae
Methods in Enzymology, 2015, 550, 301


C. Rehm, B. Klauser, J. S. Hartig
Screening of genetic aptazyme switches for conditional gene expression using a mammalian cellular system
Methods in Molecular Biology, 2015, 1316, 127


S. Ausländer , P. Stücheli , C. Rehm , D. Ausländer , J. S. Hartig, M. Fussenegger
A general design strategy for protein-responsive riboswitches in mammalian cells
Nature Methods, 2014, 11, 1154


I. Holder, J. S. Hartig,
A matter of location: Positional effects of G-quadruplexes on Escherichia coli gene expression
Chemistry & Biology, 2014, 21, 1511


B. Klauser, J. Atanasov, L. Siewert, J.S. Hartig,
Ribozyme-based aminoglycoside switches of gene expression engineered by genetic selection in S. cerevisiae
ACS Synthetic Biology, 2014, 4, 516


C. Rehm, I. T. Holder, A. Gross, F. Wojciechowski, M. Urban, M. Sinn, M. Drescher, J. S. Hartig
A bacterial DNA quadruplex with exceptional K+ selectivity and unique structural polymorphism
Chemical Science, 2014, 5, 2809


C. Rehm, J. S. Hartig
In vivo screening for aptazyme-based bacterial riboswitches
Methods in Molecular Biology, 2014, 1111, 237


P. Ketzer, J. K. Kaufmann, S. Engelhardt, S. Bossow, C. von Kalle, J. S. Hartig, G. Ungerechts, D. M. Nettelbeck
Artificial riboswitches for gene expression and replication control of DNA and RNA viruses
Proceedings of the National Academy of Sciences, 2014, 111, E554


J. S. Hartig
Binding versus Triggering Riboswitches (commentary)
Chemistry and Biology, 2014, 21, 167


A. Saragliadis, J. S. Hartig
Ribozyme-based tRNA switches for post-transcriptional control of amino acid identity in protein synthesis
Journal of the American Chemical Society, 2013, 135, 8222


A. Saragliadis, S. S. Krajewski, C. Rehm, F. Narberhaus, J. S. Hartig
Thermozymes: Synthetic RNA thermometers based on ribozyme activity
RNA Biology, 2013, 10, 1010

B. Klauser, J. S. Hartig
An engineered small RNA-mediated genetic switch based on a ribozyme expression platform
Nucleic Acids Research, 2013, 41, 5542


I. T. Holder, M. Drescher, J. S. Hartig,
Structural Characterization of Quadruplex DNA with in-cell EPR approaches
Bioorganic & Medicinal Chemistry, 2013, 21, 6156


M. Azarkh, V. Singh, O. Okle, I. T. Seemann, D. Dietrich, J. S. Hartig, M. Drescher
Site directed spin labeling of nucleotides and the use of in-cell DEER: An EPR method for determination of long-range distances in cellulo
Nature Protocols, 2013, 8, 131


P. Ketzer, S. F. Haas, S. Engelhardt, J. S. Hartig, D. Nettelbeck
Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses
Nucleic Acids Research, 2012, 40, e167


B. Klauser, A. Saragliadis, S. Ausländer, M. Wieland, M. R. Berthold, J. S. Hartig
Post-transcriptional Boolean computation by combining aptazymes controlling mRNA translation initiation and tRNA activation
Molecular Biosystems, 2012, 8, 2242


L. Giacani, S. Brandt, M. Puray-Chavez, T. Brinck Reid, C. Godornes, B. Molini, M. Benzler, J. S. Hartig, S. Lukehart, A. Centurion-Lara
Comparative Investigation of the Genomic Regions Involved in Antigenic Variation of the TprK Antigen among Treponemal Species, Subspecies, and Strains
Journal of Bacteriology, 2012, 194, 4208


V. Singh, M. Azarkh, M. Drescher, J. S. Hartig
Conformations of Individual Quadruplex Units studied in the Context of Extended Human Telomeric DNA
Chemical Communications, 2012, 48, 8258


R. Halder, J.-F. Riou, M.-P. Teulade-Fichou, T. Frickey, J. S. Hartig
Bisquinolinium Compounds induce Quadruplex-Specific Transcriptome Changes in HeLa S3 Cell Lines
BMC Research Notes, 2012, 13, 138


K. Halder, M. Benzler, J. S. Hartig,
Reporter assays for studying quadruplex nucleic acids
Methods, 2012, 57, 115


M. Azarkh, V. Singh, O. Okle, D. R. Dietrich, J. S. Hartig,* M. Drescher*
Intracellular Conformations of Human Telomeric Quadruplexes Studied by EPR
ChemPhysChem, 2012, 13, 1444


A. Saragliadis, B. Klauser, J. S. Hartig,
In vivo screening of ligand-dependent hammerhead ribozymes
Methods in Molecular Biology, 2012, 848, 455-63


V. Singh, A. Benz, J. S. Hartig:
G-quadruplexes stabilized by 8-oxo-2´-deoxyguanosine
Chemistry - A European Journal, 2011, 17, 10838


K. Halder, E. Largy, M. Benzler, M.-P. Teulade-Fichou, J. S. Hartig:
Efficient Suppression of Gene Expression by targeting 5'-UTR-based RNA Quadruplexes with Bisquinolinium Compounds
ChemBioChem, 2011, 12, 1663


M. Azarkh, O. Okle, I. Seemann, V. Singh, I. Seemann, J. S. Hartig, D. R. Dietrich, M. Drescher
Long-Range Distance Determination in a DNA Model System inside Xenopus Laevis Oocytes by In-Cell Spin-Label EPR
ChemBioChem, 2011, 12, 1992


A. Benz, V. Singh, T. U. Mayer, J. S. Hartig:
Identification of quadruplex ligands from small molecule libraries by FRET-based high-throughput screening
ChemBioChem, 2011, 12, 1422


I. T. Seemann, J. S. Hartig:
Artificial Ribozyme-Based Regulators of Gene Expression (Account)
Synlett, 2011, 11, 1486


I. T. Seemann, V. Singh, M. Azarkh, M. Drescher, J. S. Hartig:
Small molecule-triggered manipulation of DNA three-way-junctions
Journal of the American Chemical Society, 2011, 133, 4706


J. S. Hartig:
A Group I Intron Riboswitch (Commentary)
Chemistry & Biology, 2010, 17, 920


K. Halder, J. S. Hartig:
RNA Quadruplexes, in Met. Ions Life Sci ., 9
(Structural and Catalytic Roles of Metal Ions in RNA), in press


M. Wieland, B. Berschneider, M. D. Erlacher, J. S. Hartig:
Aptazyme-mediated regulation of 16S ribosomal RNA
Chemistry & Biology, 2010, 17, 236


J. S. Hartig:
Turning Riboswitches Loose (Highlight)
ChemBioChem, 2010, 11, 640


S. Ausländer, P. Ketzer, J. S. Hartig:
A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression
Molecular Biosystems, 2010, 6, 807


M. Wieland, A. Benz, J. Haar, K. Halder, J. S. Hartig:
Small molecule-triggered assembly of DNA nanoarchitectures
Chemical Communications, 2010, 46, 1866


V. Singh, M. Azarkh, T. E. Exner, J. S. Hartig*,  Malte Drescher:
Human Telomeric Quadruplex Conformations studied by pulsed EPR
Angewandte Chemie International Edition, 2009, 48, 9728 A. Joachimi, A. Benz, J. S. Hartig: A comparison of DNA and RNA quadruplex structures and stabilities Bioorganic & Medicinal Chemistry, 2009, 17, 6811 K. Halder, M. Wieland, J. S. Hartig: Predictable suppression of gene expression by 5´-UTR-based RNA quadruplexes Nucleic Acids Research, 2009, 37, 6811 B. Berschneider, M. Wieland, M. Rubini, J. S. Hartig: Small Molecule-dependent Regulation of transfer-RNA in a Bacterium Angewandte Chemie International Edition, 2009, 48, 7564 M. Wieland, J. S. Hartig: Investigation of mRNA quadruplex formation in Escherichia coli Nature Protocols, 2009, 4, 1623 M. Wieland, M. Gfell, J. S. Hartig: Expanded Hammerhead Ribozymes containing addressable Three-Way-Junctions RNA, 2009, 15, 968 M. Wieland, A. Benz, B. Klauser, J. S. Hartig: Artificial Ribozyme Switches containing natural Riboswitch Aptamer Domains Angewandte Chemie International Edition, 2009, 48, 2616 A. Henn, A. Joachimi, D. P. N. Gonçalves, D. Monchaud, M.-P. Teulade Fichou, J. K. M. Sanders, J. S. Hartig: Inhibition of Dicing of Guanosine-rich shRNAs by Quadruplex-binding Compounds ChemBioChem, 2008, 9, 2722 A. Benz, J. S. Hartig: Redesigned Tetrads with altered Hydrogen Bonding Patterns enable Programming of Quadruplex Topologies Chemical Communications, 2008, 34, 4010 M. Wieland, J. S. Hartig: Artificial Riboswitches: Synthetic mRNA-based Regulators of Gene Expression ChemBioChem, 2008, 9, 1873 Z. Tang, D. P. N. Goncalves, M. Wieland, A. Marx, J. S. Hartig: Novel DNA Catalysts based on G-quadruplex Recognition ChemBioChem, 2008, 9, 1061 M. Wieland, J. S. Hartig: An improved Aptazyme Design and in vivo Screening enable Riboswitching in Bacteria Angewandte Chemie International Edition, 2008, 47, 2604

J. S. Hartig:
Teaching Bacteria new Tricks - with RNA Switches (Highlight)
Angewandte Chemie International Edition, 2007, 46, 7741

V. Looser, S. M. Langenegger, R. Häner, J. S. Hartig:
Pyrene Modification Leads to Increased Catalytic Activity in Minimal Hammerhead Ribozymes
Chemical Communications, 2007, 42, 4357

M. Famulok, J. S. Hartig, G. Mayer
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
Chemical Reviews, 2007, 107, 3715

M. Wieland, J. S. Hartig:
RNA quadruplex-based modulation of gene expression
Chemistry & Biology, 2007, 14, 757 

S. Yamazaki, L. Tan, G. Mayer, J. S. Hartig, J. N. Song, S. Reuter, T. Restle,
S. D. Laufer, D. Grohman, H. G. Kräusslich, J. Bajorath, M. Famulok:
Aptamer displacement identifies alternative small molecule target sites that escape viral resistance
Chemistry & Biology, 2007, 14, 804 

A. Joachimi, G. Mayer, J. S. Hartig:
A new anticoagulant-antidote pair:
Control of thrombin activity by aptamers and porphyrins
Journal of the American Chemical Society, 2007, 129, 3036 

J. S. Hartig, M. Famulok:
Screening of Molecular Interactions using Reporter Hammerhead Ribozymes, in:
Molecular Beacons - signalling Nucleic Acid Probes
Methods in Molecular Biology, 2007

M. Wieland, J. S. Hartig:
Turning Inhibitors into Activators:
A Guanine-Quadruplex-controlled Hammerhead Ribozyme
Angewandte Chemie International Edition, 2006, 45, 5875 

J. S. Hartig, E. T. Kool:
Efficient isothermal expansion of human telomeric and minisatellite repeats
by Thermococcus litoralis DNA polymerase.
Nucleic Acids Research, 2005, 33(15), p4922-7

J. S. Hartig, S. Fernandez-Lopez, E. T. Kool:
Guanine-rich DNA nanocircles for the synthesis and characterization of long
cytosine-rich telomeric DNAs.
Chembiochem, 2005, 6(8), p1458-62.

J. S. Hartig
Protein-dependent ribozymes as reporters of protein-protein interactions, in:
Protein - Protein Interactions, A Molecular Cloning Manual (2nd edition)
Cold Spring Harbor Laboratory Press, 2005, p549-60 

J. S. Hartig, E. T. Kool:
Small circular DNAs for synthesis of the human telomere repeat:
Varied sizes, structures and telomere-encoding activities.
Nucleic Acids Research, 2004 , 32(19), e152 

J. S. Hartig, I. Grüne, S. H. Najafi-Shoushtari, M. Famulok:
Sequence-specific Detection of microRNAs by Signal-amplifying Ribozymes
Journal of the American Chemical Society , 2004 , 126, p722 
 
J. S. Hartig, M. Famulok:
Reporter ribozymes for domain-specific-real-time analysis of biomolecular interactions:
HIV-1-reverse transcriptase and the primer-template complex.
Angewandte Chemie International Edition , 2002 , 41, p4263 

  J. S. Hartig, S. H. Najafi-Shoushtari, I. Grüne, A. Yan, A. D. Ellington, M. Famulok:
Protein-dependent ribozymes report molecular interactions in real time.
Nature Biotechnology , 2002 , 20, p717 

A. Jenne, J. S. Hartig, N. Piganeau, A. Tauer, D. A. Samarsky, M. R. Green, J. Davies, M. Famulok:
Rapid identification and characterization of hammerhead-ribozyme inhibitors
using fluorescence-based technology.
Nature Biotechnology , 2001 , 19, p56